Vorschau

Figure_1
- Figure1E_IsPadC_dark_vs_light_Absorption_spectrum.csv
  
  24.8 kB
- Figure1F_AfAgp1_dark_vs_light_Absorption_spectrum.csv
  
  38.3 kB
Figure_3
- FSA_IsPadC_multistate_threshold72over35_mod.csv
  
  3.0 kB
- pie_chart_code.py
  
  4.3 kB
Figure_4
- FSA_AfAgp1_multistate_threshold72over35.csv
  
  2.0 kB
- FSA_IsPadC_multistate_threshold72over35.csv
  
  2.0 kB
- IsPadC_FPS_P_value01_threshold72over35.pse
  
  4.0 MB
- W174G_N175A_structure_context.pse
  
  2.4 MB
Figure_5
- Figure_5A_dark_spectra_Absorption.csv
  
  79.0 kB
- Figure_5B_light_spectra_Absorption.csv
  
  78.8 kB
- Figure_5C_thermal_reversion.csv
  
  27.6 kB
- Figure_5D_IsPadC_PSM_W174G_Absorption.csv
  
  35.5 kB
Figure_6
- Figure_6A_WT_dark_vs_light.pse
  
  14.0 MB
- Figure_6B_WT_dark_vs_W174G_dark.pse
  
  14.0 MB
- Figure_6C_WT_light_vs_N175A_light.pse
  
  13.8 MB
- HDX_tables
  - WT_dark_vs_W174G_dark
    - WT_dark_vs_W174G_dark_t1.txt
      
      6.5 kB
    - WT_dark_vs_W174G_dark_t2.txt
      
      6.5 kB
    - WT_dark_vs_W174G_dark_t3.txt
      
      6.1 kB
    - WT_dark_vs_W174G_dark_t4.txt
      
      6.1 kB
    - WT_dark_vs_W174G_dark_t5.txt
      
      6.2 kB
  - WT_dark_vs_light
    - WT_dark_vs_light_t1.txt
      
      6.5 kB
    - WT_dark_vs_light_t2.txt
      
      6.5 kB
    - WT_dark_vs_light_t3.txt
      
      6.5 kB
    - WT_dark_vs_light_t4.txt
      
      6.7 kB
    - WT_dark_vs_light_t5.txt
      
      6.8 kB
  - WT_light_vs_N175A_light
    - WT_light_vs_N175A_light_t1.txt
      
      5.7 kB
    - WT_light_vs_N175A_light_t2.txt
      
      6.4 kB
    - WT_light_vs_N175A_light_t3.txt
      
      6.2 kB
    - WT_light_vs_N175A_light_t4.txt
      
      5.8 kB
    - WT_light_vs_N175A_light_t5.txt
      
      7.0 kB
- IsPadC_PSM_N175A_dark.yaml
  
  11.5 MB
- IsPadC_PSM_N175A_light.yaml
  
  9.9 MB
- IsPadC_PSM_W174G_dark.yaml
  
  8.5 MB
- IsPadC_PSM_W174G_light.yaml
  
  8.0 MB
- IsPadC_PSM_WT_dark.yaml
  
  5.5 MB
- IsPadC_PSM_WT_light.yaml
  
  6.0 MB
Supplemental_figures
- Figure_S1
  - IsPadC_natural_sequence_alignment.fasta
    
    77.2 kB
- Figure_S11
  - comparison_FSA_versus_cagiada.csv
    
    3.0 kB
- Figure_S2
  - IsPadC_multistate_ProteinMPNN_sequences.fa
    
    582.6 kB
- Figure_S3
  - AfAgp1_natural_sequence_alignment.fasta
    
    277.0 kB
- Figure_S4
  - AfAgp1_multistate_ProteinMPNN_sequences.fa
    
    560.4 kB
- Figure_S5
  - FSA_IsPadC_multistate_threshold72over35_mod.csv
    
    3.0 kB
  - pie_chart_code.py
    
    4.3 kB
- Figure_S6
  - FSA_IsPadC_multistate_threshold72over35.csv
    
    2.0 kB
  - IsPadC_multistate_ligand_MPNN_threshold72over35.csv
    
    1.5 kB
  - Sankey_Diagram_script_FSA_final.ipynb
    
    14.5 MB
  - comparison_FSA_ProteinMPNN_Ligand_MPNN_BV_cavity_top_view.pse
    
    6.2 MB
  - comparison_FSA_ProteinMPNN_Ligand_MPNN_BV_cavity_up_view.pse
    
    6.2 MB
- Figure_S7
  - FigS7_IsPadC_PSM_E173A_dark_vs_light.csv
    
    36.5 kB
  - FigS7_IsPadC_PSM_F259M_dark_vs_light.csv
    
    29.0 kB
  - FigS7_IsPadC_PSM_M190Y_F259M_dark_vs_light.csv
    
    35.9 kB
  - FigS7_IsPadC_PSM_M190Y_dark_vs_light.csv
    
    36.5 kB
  - FigS7_IsPadC_PSM_N175A_dark_vs_light.csv
    
    36.5 kB
  - FigS7_IsPadC_PSM_P172A_dark_vs_light.csv
    
    36.2 kB
  - FigS7_IsPadC_PSM_R177Q_dark_vs_light.csv
    
    36.5 kB
  - FigS7_IsPadC_PSM_W174G_dark_vs_light.csv
    
    36.3 kB
  - FigS7_IsPadC_PSM_WT_dark_vs_light.csv
    
    36.4 kB
- Figure_S8
  - FigS8_fluorescence_data.csv
    
    43.4 kB
- Figure_S9_S10
  - Figure_S10A_left_WT_dark_vs_W174G_dark.pse
    
    14.0 MB
  - Figure_S10A_right_WT_light_vs_W174G_light.pse
    
    13.8 MB
  - Figure_S10B_left_WT_dark_vs_N175A_dark.pse
    
    14.0 MB
  - Figure_S10B_right_WT_light_vs_N175A_light.pse
    
    13.8 MB
  - HDX_tables
    - WT_dark_vs_N175A_dark
      - WT_dark_vs_N175A_dark_t1.txt
        
        6.0 kB
      - WT_dark_vs_N175A_dark_t2.txt
        
        6.5 kB
      - WT_dark_vs_N175A_dark_t3.txt
        
        6.1 kB
      - WT_dark_vs_N175A_dark_t4.txt
        
        6.4 kB
      - WT_dark_vs_N175A_dark_t5.txt
        
        6.1 kB
    - WT_dark_vs_W174G_dark
      - WT_dark_vs_W174G_dark_t1.txt
        
        6.5 kB
      - WT_dark_vs_W174G_dark_t2.txt
        
        6.5 kB
      - WT_dark_vs_W174G_dark_t3.txt
        
        6.1 kB
      - WT_dark_vs_W174G_dark_t4.txt
        
        6.1 kB
      - WT_dark_vs_W174G_dark_t5.txt
        
        6.2 kB
    - WT_light_vs_N175A_light
      - WT_light_vs_N175A_light_t1.txt
        
        5.7 kB
      - WT_light_vs_N175A_light_t2.txt
        
        6.4 kB
      - WT_light_vs_N175A_light_t3.txt
        
        6.2 kB
      - WT_light_vs_N175A_light_t4.txt
        
        5.8 kB
      - WT_light_vs_N175A_light_t5.txt
        
        7.0 kB
    - WT_light_vs_W174G_light
      - WT_light_vs_W174G_light_t1.txt
        
        5.8 kB
      - WT_light_vs_W174G_light_t2.txt
        
        5.7 kB
      - WT_light_vs_W174G_light_t3.txt
        
        5.9 kB
      - WT_light_vs_W174G_light_t4.txt
        
        5.3 kB
      - WT_light_vs_W174G_light_t5.txt
        
        6.4 kB
  - IsPadC_PSM_N175A_dark.yaml
    
    11.5 MB
  - IsPadC_PSM_N175A_light.yaml
    
    9.9 MB
  - IsPadC_PSM_W174G_dark.yaml
    
    8.5 MB
  - IsPadC_PSM_W174G_light.yaml
    
    8.0 MB
  - IsPadC_PSM_WT_dark.yaml
    
    5.5 MB
  - IsPadC_PSM_WT_light.yaml
    
    6.0 MB

Data.zip